Encoding Temporal Change of Longitudinal EBV DNA for Dynamic Risk Prediction of Nasopharyngeal Carcinoma

Inhalt:
To accurately predict the risk of recurrence and metastasis of nasopharyngeal carcinoma (NPC) patients, an image-encoded risk prediction model was proposed. 752 patients (training vs. testing: 527 vs. 225) were retrospectively collected, and the plasma EBV DNA copies were tested 13 times during treatment. Based on 13 times plasma EBV DNA copies, three kinds of image encoding methods were employed to characterize the linear and nonlinear dynamic change of longitudinal EBV DNA, i.e. Gramian Angular Summation Field (GASF), Gramian Angular Difference Field (GADF), and Recurrence Plot (RP). The Cox proportional hazard regression model was constructed by incorporating both image and clinical features as covariates to determine the risk factors and prediction models for disease-free survival (DFS). On the test set, the proposed model combining image and clinical features achieved C-index and AUC of 0.777 and 0.776, respectively outperforming the model relying solely on clinical features (C-index = 0.667, AUC = 0.675). In conclusion, the dynamic risk prediction model with image encoding can monitor changes in plasma EBV DNA copies during treatment, aiding doctors in assessing whole-body tumor burden, accurately predicting the dynamic risk of recurrence and metastasis, and planning individualized treatments in NPC patients.