A Review of UGT2B17 Gene Polymorphisms-Associated Diseases and Doping Control

Abstract:
This article provides a summary of research based on relevant domestic and international literature, focusing on the importance of UDP-glucuronosyltransferase (UGT) and the impact of UGT2B17 gene polymorphisms on disease and biomarker detection. UGT2B17, as a member of the UGT superfamily, influences the development of different diseases by altering inter-individual glucuronidation activity. The polymorphisms of this gene are caused by DNA sequence of approximately 120 kb insertion and deletion on chromosome 4, and significantly affect the metabolism of steroid hormones. When conducting doping-control of athlete samples, it is necessary to pay extra attention to the influence of UGT2B17 gene polymorphisms on the results. These research findings are of significant importance for disease prevention and biomarker detection.