The positive effect of metformin on reproduction is through its action on AMPK in GT1-7 cells to regulate KISS1R, and GNRH1 expression
Conference: BIBE 2019 - The Third International Conference on Biological Information and Biomedical Engineering
06/20/2019 - 06/22/2019 at Hangzhou, China
Proceedings: BIBE 2019
Pages: 4Language: englishTyp: PDF
Personal VDE Members are entitled to a 10% discount on this title
Authors:
Fu, Jingyun; Qu, Xuan; Zhong, Jun; Zhang, Ping (Division of Endocrinology, First affiliated hospital of Kunming medical university, Kunming, Yunnan, China)
Abstract:
AMP-Activated Kinase (AMPK) is a nutrient and energy sensor that regulates energy homeostasis. Metformin, an activator of AMPK, improves fertility and metabolic profile in women with Polycystic ovarian syndrome (PCOS). PCOS, a common cause of infertility in women, is associated with metabolic disorders.We hypothesize that the positive effect of metformin on reproduction is through its action on AMPK in GnRH neurons to regulate KISS1R, and GNRH1 expression. Our objective was to measure Ampkalpha, Kiss1r, and Gnrh1 mRNA expression in GT1-7 cells, a murine GnRH neuronal cell line, following treatment with metforming or an AMPK agonist (5-aminoimidazole-4-carboxamide ribonucleoside -AICAR).