An Integrated FOPP Detector for Β Cell Function Monitoring

Abstract:
This paper presents an integrated circuit for β-cell burst detection and monitoring, which will be used for the study of the type 2 diabetes mellitus. A unique feature of the design is an integrated circuit solution for the Fraction of Plateau Phase (FOPP) detection. The FOPP is the percentage of time when β-cells, in the islets of Langerhans in the pancreas, show burst activity, which is directly proportional to the extracellular glucose concentration. The proposed integrated FOPP detector circuit adopting a differential envelope detector structure keeps the design overhead to a minimum and only FOPP relevant information is well reserved and processed, resulting in a highly reduced data volume.